Effect of co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 on anxiolytic effect of …
I Muraki, T Inoue, T Koyama - European journal of pharmacology, 2008 - Elsevier
This study investigated the effect of co-administration of the selective 5-HT1A receptor
antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 with a
subactive dose of citalopram [selective serotonin (5-HT) reuptake inhibitor (SSRI)] on the
expression of conditioned freezing, an index of fear. In the present study, acute
administration of citalopram (sc) reduced freezing significantly at high doses (10, 30 and 100
mg/kg), while showing no significant effect at low doses (1 and 3 mg/kg). Co-administration …
antagonist WAY 100,635 and selective 5-HT1B/1D receptor antagonist GR 127,935 with a
subactive dose of citalopram [selective serotonin (5-HT) reuptake inhibitor (SSRI)] on the
expression of conditioned freezing, an index of fear. In the present study, acute
administration of citalopram (sc) reduced freezing significantly at high doses (10, 30 and 100
mg/kg), while showing no significant effect at low doses (1 and 3 mg/kg). Co-administration …
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